Journal of Advanced Pharmacy Education & Research
 
 
Year : 2014   |  Volume : 4   |  Issue : 1   |  Page : 54-58  

Effect of novel inhibitor of protein tyrosine phosphatase PTP 1B (NCE-9) on the amelioration of hyperglycemia in DIO mice

Chandrashekhar L Athare, Chandrashekhar D Upasani

Correspondence Address:Department of Pharmacology, Faculty of Pharmacy, Shri Neminath Jain Bramhacharyashram's Shriman Sureshdada Jain College of Pharmacy, Jain Gurukul, Chandwad, Nasik, Maharashtra, India-423 101

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.197331

Abstract  

Metabolic syndrome and type 2 diabetes are complex disorders that are associated with obesity, aging, and genetic predisposition. The increasing prevalence of metabolic abnormalities worldwide presents a serious public health problem, with rates of obesity and diabetes reaching unprecedented levels. A common feature of these disorders is the development of insulin resistance, resulting in decreased insulin-stimulated glucose uptake, failure to suppress hepatic glucose production, and accumulation of hepatic lipid. Recent studies in mice have shown that deficiency of the non-receptor protein tyrosine phosphatase, PTP1B, in liver leads to a host of improvements in metabolic parameters, including improved hepatic insulin sensitivity, reduced liver triglycerides, lower serum and hepatic cholesterol levels, and protection against high-fat diet induced endoplasmic reticulum (ER) stress. Based on these promising studies, PTP1B inhibitors may prove to be a valuable therapeutic tool in the fight against metabolic syndrome and its associated comorbidities. In this study, we investigate effect of NCE-9 in diet induced obese (DIO) mice. NCE-9 significantly improved hyperglycemia and insulin resistance in DIO mice when orally administered at a dose of 30 and 100 mg/kg/day for 28 days. Overall, these studies suggest that NCE-9 improves insulin sensitivity and improves glucose tolerance in animal models through inhibition of PTP1B and that it would be a new therapeutic candidate with potential for the treatment of type 2 diabetic patients.

Keywords: NCE-9, Protein tyrosine phosphatase 1B, Insulin resistant, DIO mice

How to cite this article:
Chandrashekhar L Athare*,

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