Journal of Advanced Pharmacy Education & Research
 
 
Year : 2014   |  Volume : 4   |  Issue : 1   |  Page : 125-133  

Anti-cytokine and anti-hyperalgesic effects of aliskiren in experimental models of inflammation

Rakesh B. Patel, Kanaiyalal D. Prajapati, Bhavin M. Sonara, Manoranjan M. Sharma, Vishwanath D. Pawar, Mukul R. Jain

Correspondence Address:Department of Pharmacology, Zydus Research Centre, SarkhejBavla National Highway-8A, Moraiya, Ahmedabad 382 213, Gujarat, India.

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.197331

Abstract  

The renin-angiotensin system is involved in pathogenesis and progression of inflammatory responses. In present study, we investigated the anti-cytokine and anti-hyperalgesic potential of aliskiren in LPS (lipopolysaccharide) and CFA (complete Freund’s adjuvant) induced inflammation in rodents. After aliskiren treatment, plasma cytokines (TNF-a, IL-6) and plasma renin activity (PRA) were estimated in LPS treated mice. In CFA induced inflammatory pain model, rats were treated with aliskiren and thermal hyperalgesia was evaluated and TNF-a and IL-6 were estimated in paw. In LPS treated ICR mice, elevated TNF-a and IL-6 levels and PRA were attenuated by aliskiren. In LPS treated double transgenic mice (dTG), harboring human renin and human angiotensinogen and C57BL/6J mice, elevated TNF-a level was inhibited by aliskiren. Moreover after LPS treatment, TNF-a level was high (2.16 fold) in dTG mice than C57BL/6J. These data indicates that renin overexpression system in dTG mice is responsible for higher TNF-a level suggests role of renin in inflammation. Moreover, Aliskiren showed anti-hyperalgesic activity in CFA induced inflammatory hyperalgesia in rats, which might be due to inhibition TNF-a and IL- 6 levels, suggests the role of local renin in inflammation. Our results indicate the role of renin in experimental inflammation which is inhibited by aliskiren.

Keywords: Aliskiren; renin; CFA; LPS; inflammation; cytokine

How to cite this article:
: Rakesh B. Patel*, Kanaiyalal D.

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