Journal of Advanced Pharmacy Education & Research
 
 
Year : 2012   |  Volume : 2   |  Issue : 3   |  Page : 128-136  

Formulation and Evaluation of Caffeine Loaded Floating Tablets

Mohit Tomar , Neha Tomar, Neha Gulati, Upendra Nagaich, Amit Chaudhary, Bhavya Rastogi

Correspondence Address:Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology, By-Pass Road, Partapur, Meerut-250103, Uttar Pradesh, India

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-4040.197331

Abstract  

The aim of the present work was to fabricate and characterize caffeine loaded floating tablets loaded as sustained release dosage forms. Several formulations were prepared by varying the concentrations of sodium bicarbonate and citric acid. Floating tablets were prepared using HPMC as a binder and sodium bicarbonate as gas generating agents. The prepared floating tablets were evaluated for tablet properties such as hardness, thickness, friability, weight variation and floating property. In vitro dissolution was conceded out for about 16 hrs in 0.1N HCl at 37±0.5 °C using USP paddle type dissolution apparatus. It was noted that, all the prepared formulations had desired floating lag time and constantly floated on dissolution medium. The drug release from floating tablets was found that the varying concentration of the polymer affected the drug release. In the present surveillance that floating drug delivery system can be prepared and evaluated.

Keywords: Floating Tablets, Caffeine, Hydrodynamically balance system, Effervescence, Sustain Release, Sodium bicarbonate.

How to cite this article:
None

Introduction   Top

Materials and methods   Top

Results Discussion   Top

Conclusion   Top

Acknowledgement   Top

References   Top

Figures